Drug interactions
Fluticasone inhaled + Ribociclib
Severity: Moderate
Fluticasone inhaled and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluticasone is extensively cleared by CYP3A4, and strong inhibitors have caused systemic corticosteroid effects including Cushing syndrome and adrenal suppression. Ribociclib inhibits CYP3A4 and may raise systemic fluticasone exposure, especially with long-term high-dose use.
What this interaction means in plain words
Fluticasone inhaled and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ribociclib inhibits CYP3A4, reducing first-pass and systemic clearance of fluticasone.
What to do
Monitor for signs of Cushingoid features and adrenal suppression with prolonged use. Consider an alternative inhaled steroid such as beclomethasone if long-term therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluticasone inhaled and Ribociclib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Fluticasone inhaled with Ribociclib?
MediHelp rates the interaction as moderate. Fluticasone inhaled and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluticasone is extensively cleared by CYP3A4, and strong inhibitors have caused systemic corticosteroid effects including Cushing syndrome and adrenal suppression. Ribociclib inhibits CYP3A4 and may raise systemic fluticasone exposure, especially with long-term high-dose use.
How serious is the interaction between Fluticasone inhaled and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of Cushingoid features and adrenal suppression with prolonged use. Consider an alternative inhaled steroid such as beclomethasone if long-term therapy is needed.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
