Drug interactions
Fluticasone inhaled + Voriconazole
Severity: Major
Fluticasone inhaled and Voriconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inhibitors markedly increase systemic fluticasone exposure, and Cushing syndrome and adrenal suppression have been reported with ritonavir and azoles. Voriconazole may produce similar effects with prolonged use.
What this interaction means in plain words
Fluticasone inhaled and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Voriconazole inhibits CYP3A4, reducing first-pass and systemic clearance of fluticasone.
What to do
Consider an alternative corticosteroid such as beclomethasone for long-term therapy; otherwise monitor for Cushingoid features and adrenal suppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Fluticasone inhaled with Voriconazole?
MediHelp rates the interaction as major. Fluticasone inhaled and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 inhibitors markedly increase systemic fluticasone exposure, and Cushing syndrome and adrenal suppression have been reported with ritonavir and azoles. Voriconazole may produce similar effects with prolonged use.
How serious is the interaction between Fluticasone inhaled and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative corticosteroid such as beclomethasone for long-term therapy; otherwise monitor for Cushingoid features and adrenal suppression.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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