Drug interactions
Fluticasone intranasal + Itraconazole
Severity: Moderate
Fluticasone intranasal and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole can raise systemic fluticasone exposure by blocking its CYP3A4 metabolism. This may lead to systemic corticosteroid effects including Cushing's syndrome and adrenal suppression, mostly with prolonged use.
What this interaction means in plain words
Fluticasone intranasal and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Strong CYP3A4 inhibition reduces first-pass and systemic clearance of fluticasone.
What to do
For prolonged co-therapy consider an alternative corticosteroid such as beclomethasone. Otherwise monitor for Cushingoid features and adrenal suppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Fluticasone intranasal with Itraconazole?
MediHelp rates the interaction as moderate. Fluticasone intranasal and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole can raise systemic fluticasone exposure by blocking its CYP3A4 metabolism. This may lead to systemic corticosteroid effects including Cushing's syndrome and adrenal suppression, mostly with prolonged use.
How serious is the interaction between Fluticasone intranasal and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For prolonged co-therapy consider an alternative corticosteroid such as beclomethasone. Otherwise monitor for Cushingoid features and adrenal suppression.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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