Drug interactions
Fluticasone intranasal + Ribociclib
Severity: Minor
Fluticasone intranasal and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal fluticasone has low systemic exposure but is cleared by CYP3A4. Ribociclib may increase systemic levels, though clinically relevant corticosteroid effects are uncommon at recommended doses.
What this interaction means in plain words
Fluticasone intranasal and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ribociclib inhibits CYP3A4, reducing fluticasone clearance.
What to do
Usually no change is needed; use the lowest effective dose and watch for systemic steroid effects with prolonged therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Fluticasone intranasal with Ribociclib?
MediHelp rates the interaction as minor. Fluticasone intranasal and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Intranasal fluticasone has low systemic exposure but is cleared by CYP3A4. Ribociclib may increase systemic levels, though clinically relevant corticosteroid effects are uncommon at recommended doses.
How serious is the interaction between Fluticasone intranasal and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change is needed; use the lowest effective dose and watch for systemic steroid effects with prolonged therapy.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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