Drug interactions
Fluticasone intranasal + Voriconazole
Severity: Moderate
Fluticasone intranasal and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and can increase systemic exposure to fluticasone, which normally has very low systemic availability. Prolonged coadministration may cause systemic corticosteroid effects such as Cushing syndrome and adrenal suppression.
What this interaction means in plain words
Fluticasone intranasal and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP3A4-mediated first-pass and systemic metabolism of fluticasone.
What to do
For short courses, monitor for corticosteroid excess; for long-term use consider an alternative intranasal steroid less dependent on CYP3A4, such as beclomethasone. Monitor for Cushingoid features and adrenal suppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Fluticasone intranasal with Voriconazole?
MediHelp rates the interaction as moderate. Fluticasone intranasal and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4 and can increase systemic exposure to fluticasone, which normally has very low systemic availability. Prolonged coadministration may cause systemic corticosteroid effects such as Cushing syndrome and adrenal suppression.
How serious is the interaction between Fluticasone intranasal and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For short courses, monitor for corticosteroid excess; for long-term use consider an alternative intranasal steroid less dependent on CYP3A4, such as beclomethasone. Monitor for Cushingoid features and adrenal suppression.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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