Drug interactions
Fluticasone-salmeterol + Fostemsavir
Severity: Moderate
Fluticasone-salmeterol and Fostemsavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol can prolong the QT interval, and fostemsavir has caused QT prolongation at supratherapeutic doses. Combined use could add to arrhythmia risk, although the risk at recommended fostemsavir doses is low.
What this interaction means in plain words
Fluticasone-salmeterol and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Fostemsavir belongs to Anti Virals.
Why it happens
Additive effects on cardiac repolarization (QT prolongation).
What to do
Consider baseline and follow-up ECG in patients with other QT risk factors, and correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Fostemsavir?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salmeterol can prolong the QT interval, and fostemsavir has caused QT prolongation at supratherapeutic doses. Combined use could add to arrhythmia risk, although the risk at recommended fostemsavir doses is low.
How serious is the interaction between Fluticasone-salmeterol and Fostemsavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider baseline and follow-up ECG in patients with other QT risk factors, and correct hypokalemia and hypomagnesemia.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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