Drug interactions
Fluticasone-salmeterol + Imatinib
Severity: Minor
Fluticasone-salmeterol and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4 and may raise systemic fluticasone exposure, although it is a moderate rather than strong inhibitor. Raised exposure could cause systemic corticosteroid effects such as adrenal suppression, but this is uncommon with usual inhaled doses.
What this interaction means in plain words
Fluticasone-salmeterol and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-salmeterol belongs to Respiratory; Imatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of fluticasone.
What to do
Monitor for signs of systemic corticosteroid excess during long-term combined use. Use the lowest effective fluticasone dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Fluticasone-salmeterol with Imatinib?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib inhibits CYP3A4 and may raise systemic fluticasone exposure, although it is a moderate rather than strong inhibitor. Raised exposure could cause systemic corticosteroid effects such as adrenal suppression, but this is uncommon with usual inhaled doses.
How serious is the interaction between Fluticasone-salmeterol and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of systemic corticosteroid excess during long-term combined use. Use the lowest effective fluticasone dose.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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