Drug interactions
Fluticasone-salmeterol + Isoproterenol
Severity: Major
Fluticasone-salmeterol and Isoproterenol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoproterenol and salmeterol are both beta-adrenergic agonists, so using them together can intensify tachycardia, palpitations, hypertension, tremor and hypokalemia. Patients with cardiac disease are at greatest risk of arrhythmia.
What this interaction means in plain words
Fluticasone-salmeterol and Isoproterenol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-salmeterol belongs to Respiratory; Isoproterenol belongs to Respiratory.
Why it happens
Additive beta-adrenergic receptor stimulation affecting the heart and potassium handling.
What to do
Avoid concurrent use where possible; if needed, monitor heart rate, ECG and serum potassium closely. Use the lowest effective doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Isoproterenol
Frequently asked questions
Can I take Fluticasone-salmeterol with Isoproterenol?
MediHelp rates the interaction as major. Fluticasone-salmeterol and Isoproterenol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Isoproterenol and salmeterol are both beta-adrenergic agonists, so using them together can intensify tachycardia, palpitations, hypertension, tremor and hypokalemia. Patients with cardiac disease are at greatest risk of arrhythmia.
How serious is the interaction between Fluticasone-salmeterol and Isoproterenol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if needed, monitor heart rate, ECG and serum potassium closely. Use the lowest effective doses.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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