Drug interactions
Fluticasone-salmeterol + Mifepristone
Severity: Moderate
Fluticasone-salmeterol and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and can increase systemic exposure to both salmeterol and inhaled fluticasone. Higher salmeterol levels may cause tachycardia, QT prolongation and hypokalemia, while higher fluticasone levels may cause systemic corticosteroid effects.
What this interaction means in plain words
Fluticasone-salmeterol and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated metabolism of salmeterol and fluticasone by mifepristone.
What to do
Monitor for cardiovascular effects, hypokalemia and signs of corticosteroid excess such as adrenal suppression. Consider an alternative inhaled regimen if long-term or high-dose mifepristone is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Mifepristone?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and can increase systemic exposure to both salmeterol and inhaled fluticasone. Higher salmeterol levels may cause tachycardia, QT prolongation and hypokalemia, while higher fluticasone levels may cause systemic corticosteroid effects.
How serious is the interaction between Fluticasone-salmeterol and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cardiovascular effects, hypokalemia and signs of corticosteroid excess such as adrenal suppression. Consider an alternative inhaled regimen if long-term or high-dose mifepristone is needed.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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