Drug interactions
Fluticasone-salmeterol + Nadolol
Severity: Major
Fluticasone-salmeterol and Nadolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol is a non-selective beta-blocker that blocks the beta-2 receptors salmeterol acts on, reducing bronchodilation and potentially provoking bronchospasm in patients with asthma or COPD. The combination undermines the purpose of the inhaler.
What this interaction means in plain words
Fluticasone-salmeterol and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-salmeterol belongs to Respiratory; Nadolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors by a non-selective beta-blocker.
What to do
Avoid non-selective beta-blockers in patients with asthma; if a beta-blocker is essential in COPD, choose a cardioselective agent. Monitor respiratory function and rescue inhaler use.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Nadolol
Frequently asked questions
Can I take Fluticasone-salmeterol with Nadolol?
MediHelp rates the interaction as major. Fluticasone-salmeterol and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nadolol is a non-selective beta-blocker that blocks the beta-2 receptors salmeterol acts on, reducing bronchodilation and potentially provoking bronchospasm in patients with asthma or COPD. The combination undermines the purpose of the inhaler.
How serious is the interaction between Fluticasone-salmeterol and Nadolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid non-selective beta-blockers in patients with asthma; if a beta-blocker is essential in COPD, choose a cardioselective agent. Monitor respiratory function and rescue inhaler use.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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