Drug interactions
Fluticasone-salmeterol + Nebivolol
Severity: Moderate
Fluticasone-salmeterol and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol is a beta-1 selective blocker, so it has less effect on salmeterol's bronchodilation than non-selective agents. At higher doses selectivity is lost and it may reduce salmeterol's effect or provoke bronchospasm in susceptible patients.
What this interaction means in plain words
Fluticasone-salmeterol and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Nebivolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta-adrenergic receptors, limited by beta-1 selectivity.
What to do
Use the lowest effective nebivolol dose and monitor symptoms, peak flow and rescue inhaler use in patients with reactive airway disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Fluticasone-salmeterol with Nebivolol?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nebivolol is a beta-1 selective blocker, so it has less effect on salmeterol's bronchodilation than non-selective agents. At higher doses selectivity is lost and it may reduce salmeterol's effect or provoke bronchospasm in susceptible patients.
How serious is the interaction between Fluticasone-salmeterol and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective nebivolol dose and monitor symptoms, peak flow and rescue inhaler use in patients with reactive airway disease.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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