Drug interactions
Fluticasone-salmeterol + Quetiapine
Severity: Moderate
Fluticasone-salmeterol and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine and salmeterol can both prolong the QT interval, and salmeterol may cause hypokalemia, which increases arrhythmia risk. The effect is modest at usual inhaled doses.
What this interaction means in plain words
Fluticasone-salmeterol and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Quetiapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia contributing.
What to do
Check ECG and potassium in patients with other QT risk factors, and avoid exceeding recommended salmeterol doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Fluticasone-salmeterol with Quetiapine?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine and salmeterol can both prolong the QT interval, and salmeterol may cause hypokalemia, which increases arrhythmia risk. The effect is modest at usual inhaled doses.
How serious is the interaction between Fluticasone-salmeterol and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and potassium in patients with other QT risk factors, and avoid exceeding recommended salmeterol doses.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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