Drug interactions
Fluticasone-salmeterol + Quinidine
Severity: Moderate
Fluticasone-salmeterol and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is not a strong CYP3A4 inhibitor, so a meaningful rise in fluticasone exposure is unlikely. However, quinidine and salmeterol can both prolong the QT interval, particularly if hypokalemia occurs.
What this interaction means in plain words
Fluticasone-salmeterol and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Quinidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia contributing.
What to do
Monitor ECG and potassium, especially at the start of therapy or with higher salmeterol doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Quinidine?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine is not a strong CYP3A4 inhibitor, so a meaningful rise in fluticasone exposure is unlikely. However, quinidine and salmeterol can both prolong the QT interval, particularly if hypokalemia occurs.
How serious is the interaction between Fluticasone-salmeterol and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and potassium, especially at the start of therapy or with higher salmeterol doses.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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