Drug interactions
Fluticasone-salmeterol + Sulindac
Severity: Minor
Fluticasone-salmeterol and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No clinically meaningful interaction is established between sulindac and inhaled salmeterol or fluticasone. NSAIDs can rarely raise potassium, while salmeterol may slightly lower it.
What this interaction means in plain words
Fluticasone-salmeterol and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-salmeterol belongs to Respiratory; Sulindac belongs to Musculoskeletal.
Why it happens
Opposing minor effects on serum potassium; no established mechanism of significance.
What to do
No specific action required beyond routine monitoring of potassium and renal function in at-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Fluticasone-salmeterol with Sulindac?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No clinically meaningful interaction is established between sulindac and inhaled salmeterol or fluticasone. NSAIDs can rarely raise potassium, while salmeterol may slightly lower it.
How serious is the interaction between Fluticasone-salmeterol and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action required beyond routine monitoring of potassium and renal function in at-risk patients.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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