Drug interactions
Fluticasone-salmeterol + Tolfenamic acid
Severity: Minor
Fluticasone-salmeterol and Tolfenamic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No clinically meaningful interaction is established between tolfenamic acid and inhaled salmeterol or fluticasone. NSAIDs may rarely provoke bronchospasm in aspirin-sensitive asthma, but that is independent of this combination.
What this interaction means in plain words
Fluticasone-salmeterol and Tolfenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-salmeterol belongs to Respiratory; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
No established pharmacological mechanism; minor opposing potassium effects are theoretical.
What to do
No specific action; ask about NSAID-sensitive asthma before use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Fluticasone-salmeterol with Tolfenamic acid?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Tolfenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No clinically meaningful interaction is established between tolfenamic acid and inhaled salmeterol or fluticasone. NSAIDs may rarely provoke bronchospasm in aspirin-sensitive asthma, but that is independent of this combination.
How serious is the interaction between Fluticasone-salmeterol and Tolfenamic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action; ask about NSAID-sensitive asthma before use.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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