Drug interactions
Fluticasone-vilanterol + Foscarnet
Severity: Major
Fluticasone-vilanterol and Foscarnet: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Foscarnet can prolong the QT interval and cause hypokalemia, hypocalcemia and hypomagnesemia, which increase arrhythmia risk. Vilanterol can add to the hypokalemia and cardiac stimulation.
What this interaction means in plain words
Fluticasone-vilanterol and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Foscarnet belongs to Anti Virals.
Why it happens
Additive QTc prolongation, aggravated by foscarnet-induced electrolyte disturbances and beta-agonist potassium lowering.
What to do
Monitor electrolytes closely and correct deficits, and obtain ECG monitoring during foscarnet therapy. Consider alternatives to the LABA if QT prolongation develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Foscarnet?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Foscarnet can prolong the QT interval and cause hypokalemia, hypocalcemia and hypomagnesemia, which increase arrhythmia risk. Vilanterol can add to the hypokalemia and cardiac stimulation.
How serious is the interaction between Fluticasone-vilanterol and Foscarnet?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes closely and correct deficits, and obtain ECG monitoring during foscarnet therapy. Consider alternatives to the LABA if QT prolongation develops.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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