Drug interactions
Fluticasone-vilanterol + Givinostat
Severity: Moderate
Fluticasone-vilanterol and Givinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QT interval, and vilanterol may add to the cardiac effect and lower potassium. Together they may increase the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Fluticasone-vilanterol and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Givinostat belongs to Miscellaneous.
Why it happens
Additive QT prolongation with beta2-agonist-related hypokalemia.
What to do
Perform ECGs at the start of combined use and periodically thereafter, and correct electrolytes. Interrupt givinostat if QTc becomes markedly prolonged, as set out in its labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Givinostat?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat can prolong the QT interval, and vilanterol may add to the cardiac effect and lower potassium. Together they may increase the risk of serious ventricular arrhythmias.
How serious is the interaction between Fluticasone-vilanterol and Givinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECGs at the start of combined use and periodically thereafter, and correct electrolytes. Interrupt givinostat if QTc becomes markedly prolonged, as set out in its labeling.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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