Drug interactions
Fluticasone-vilanterol + Imipramine
Severity: Major
Fluticasone-vilanterol and Imipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine can potentiate the cardiovascular effects of vilanterol, causing tachycardia, blood pressure changes and arrhythmias. Both agents may also prolong QTc.
What this interaction means in plain words
Fluticasone-vilanterol and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Imipramine belongs to Central Nervous System.
Why it happens
Tricyclics block noradrenaline reuptake and have quinidine-like effects, augmenting beta-agonist cardiac stimulation and QTc prolongation.
What to do
Monitor heart rate, blood pressure and ECG when used together, especially at initiation or dose changes. Consider alternative antidepressants in patients with cardiac disease.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Imipramine?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imipramine can potentiate the cardiovascular effects of vilanterol, causing tachycardia, blood pressure changes and arrhythmias. Both agents may also prolong QTc.
How serious is the interaction between Fluticasone-vilanterol and Imipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG when used together, especially at initiation or dose changes. Consider alternative antidepressants in patients with cardiac disease.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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