Drug interactions
Fluticasone-vilanterol + Isocarboxazid
Severity: Major
Fluticasone-vilanterol and Isocarboxazid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can exaggerate the cardiovascular effects of beta2-agonists, causing tachycardia, hypertension and arrhythmias. The effect can persist for about two weeks after stopping the MAOI.
What this interaction means in plain words
Fluticasone-vilanterol and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Isocarboxazid belongs to Central Nervous System.
Why it happens
MAO inhibition increases catecholamine stores and potentiates adrenergic stimulation from the beta-agonist.
What to do
Avoid the combination where possible, including within two weeks of stopping the MAOI. If unavoidable, monitor blood pressure, heart rate and ECG closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Isocarboxazid?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MAO inhibitors can exaggerate the cardiovascular effects of beta2-agonists, causing tachycardia, hypertension and arrhythmias. The effect can persist for about two weeks after stopping the MAOI.
How serious is the interaction between Fluticasone-vilanterol and Isocarboxazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, including within two weeks of stopping the MAOI. If unavoidable, monitor blood pressure, heart rate and ECG closely.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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