Drug interactions
Fluticasone-vilanterol + Larotrectinib
Severity: Minor
Fluticasone-vilanterol and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a modest CYP3A4 inhibitor and could marginally raise exposure to fluticasone furoate and vilanterol. Clinical impact is expected to be small.
What this interaction means in plain words
Fluticasone-vilanterol and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-vilanterol belongs to Respiratory; Larotrectinib belongs to Oncology.
Why it happens
Larotrectinib weakly inhibits CYP3A4, slightly reducing clearance of the inhaled substrates.
What to do
No routine adjustment is required; monitor for beta-agonist adverse effects such as palpitations and tremor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-vilanterol
Other interactions of Larotrectinib
Frequently asked questions
Can I take Fluticasone-vilanterol with Larotrectinib?
MediHelp rates the interaction as minor. Fluticasone-vilanterol and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a modest CYP3A4 inhibitor and could marginally raise exposure to fluticasone furoate and vilanterol. Clinical impact is expected to be small.
How serious is the interaction between Fluticasone-vilanterol and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; monitor for beta-agonist adverse effects such as palpitations and tremor.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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