Drug interactions
Fluticasone-vilanterol + Lefamulin
Severity: Moderate
Fluticasone-vilanterol and Lefamulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin inhibits CYP3A4 and may raise exposure to the CYP3A4 substrates vilanterol and fluticasone furoate. Vilanterol can contribute to QT prolongation and tachycardia, as can lefamulin, though the label contraindication applies to oral lefamulin with QT-prolonging CYP3A substrates.
What this interaction means in plain words
Fluticasone-vilanterol and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Lefamulin belongs to Anti Bacterial.
Why it happens
CYP3A4 inhibition by lefamulin increases vilanterol and fluticasone exposure, with additive QT effects.
What to do
Monitor for tachycardia, palpitations and QT prolongation, and consider ECG in patients with cardiac risk factors. Consider an alternative antibiotic if risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Lefamulin?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin inhibits CYP3A4 and may raise exposure to the CYP3A4 substrates vilanterol and fluticasone furoate. Vilanterol can contribute to QT prolongation and tachycardia, as can lefamulin, though the label contraindication applies to oral lefamulin with QT-prolonging CYP3A substrates.
How serious is the interaction between Fluticasone-vilanterol and Lefamulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tachycardia, palpitations and QT prolongation, and consider ECG in patients with cardiac risk factors. Consider an alternative antibiotic if risk is high.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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