Drug interactions
Fluticasone-vilanterol + Methadone
Severity: Major
Fluticasone-vilanterol and Methadone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methadone causes dose-related QT prolongation and torsades de pointes, and vilanterol can add to this through adrenergic effects and hypokalemia. Risk is higher at high methadone doses.
What this interaction means in plain words
Fluticasone-vilanterol and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Methadone belongs to Musculoskeletal.
Why it happens
Additive QTc prolongation via hERG blockade plus beta-agonist potassium lowering.
What to do
Obtain ECG at baseline and after dose changes, and correct potassium and magnesium. Use the lowest effective methadone dose and watch for palpitations or syncope.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluticasone-vilanterol and Methadone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluticasone-vilanterol
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Methadone?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methadone causes dose-related QT prolongation and torsades de pointes, and vilanterol can add to this through adrenergic effects and hypokalemia. Risk is higher at high methadone doses.
How serious is the interaction between Fluticasone-vilanterol and Methadone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECG at baseline and after dose changes, and correct potassium and magnesium. Use the lowest effective methadone dose and watch for palpitations or syncope.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
