Drug interactions
Fluticasone-vilanterol + Nelfinavir
Severity: Moderate
Fluticasone-vilanterol and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and can increase exposure to fluticasone furoate and vilanterol. This may result in systemic corticosteroid effects and increased beta-agonist cardiovascular effects.
What this interaction means in plain words
Fluticasone-vilanterol and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Nelfinavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of fluticasone furoate and vilanterol.
What to do
Monitor for adrenal suppression, tachycardia and hypokalemia. Consider an alternative inhaled corticosteroid for long-term therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Nelfinavir?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir inhibits CYP3A4 and can increase exposure to fluticasone furoate and vilanterol. This may result in systemic corticosteroid effects and increased beta-agonist cardiovascular effects.
How serious is the interaction between Fluticasone-vilanterol and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adrenal suppression, tachycardia and hypokalemia. Consider an alternative inhaled corticosteroid for long-term therapy.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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