Drug interactions
Fluticasone-vilanterol + Nilotinib
Severity: Moderate
Fluticasone-vilanterol and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib prolongs the QT interval, and beta-2 agonists such as vilanterol can add to cardiac effects including tachycardia, hypokalemia and QT changes. Together they may increase the risk of ventricular arrhythmias, although systemic vilanterol exposure from inhalation is low.
What this interaction means in plain words
Fluticasone-vilanterol and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Nilotinib belongs to Oncology.
Why it happens
Additive effects on cardiac repolarization and adrenergic cardiovascular stimulation.
What to do
Check baseline ECG and correct potassium and magnesium before and during combined use; monitor ECG and symptoms of palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Nilotinib?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib prolongs the QT interval, and beta-2 agonists such as vilanterol can add to cardiac effects including tachycardia, hypokalemia and QT changes. Together they may increase the risk of ventricular arrhythmias, although systemic vilanterol exposure from inhalation is low.
How serious is the interaction between Fluticasone-vilanterol and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium before and during combined use; monitor ECG and symptoms of palpitations or syncope.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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