Drug interactions
Fluticasone-vilanterol + Nortriptyline
Severity: Moderate
Fluticasone-vilanterol and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists, leading to higher heart rate, blood pressure changes and arrhythmias. Nortriptyline also prolongs the QT interval, adding to the proarrhythmic potential.
What this interaction means in plain words
Fluticasone-vilanterol and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Nortriptyline belongs to Central Nervous System.
Why it happens
Tricyclics potentiate adrenergic vascular and cardiac effects and add QT-prolonging effects.
What to do
Monitor heart rate, blood pressure and ECG when starting or adjusting either drug, particularly in patients with cardiac disease; consider an alternative antidepressant in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluticasone-vilanterol and Nortriptyline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluticasone-vilanterol
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Nortriptyline?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists, leading to higher heart rate, blood pressure changes and arrhythmias. Nortriptyline also prolongs the QT interval, adding to the proarrhythmic potential.
How serious is the interaction between Fluticasone-vilanterol and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG when starting or adjusting either drug, particularly in patients with cardiac disease; consider an alternative antidepressant in high-risk patients.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
