Drug interactions
Fluticasone-vilanterol + Pasireotide
Severity: Moderate
Fluticasone-vilanterol and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide can lengthen the QTc interval and slow heart rate. Vilanterol may add to cardiac repolarization effects and raise heart rate, so arrhythmia risk could increase in susceptible patients.
What this interaction means in plain words
Fluticasone-vilanterol and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Pasireotide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization.
What to do
Check baseline QTc and potassium and magnesium before starting and correct any deficits. Monitor ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Pasireotide?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide can lengthen the QTc interval and slow heart rate. Vilanterol may add to cardiac repolarization effects and raise heart rate, so arrhythmia risk could increase in susceptible patients.
How serious is the interaction between Fluticasone-vilanterol and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline QTc and potassium and magnesium before starting and correct any deficits. Monitor ECG in patients with other QT risk factors.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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