Drug interactions
Fluticasone-vilanterol + Primidone
Severity: Minor
Fluticasone-vilanterol and Primidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is partly converted to phenobarbital, a CYP3A4 inducer, so it may lower systemic levels of fluticasone furoate and vilanterol. The clinical effect is probably small but could reduce disease control.
What this interaction means in plain words
Fluticasone-vilanterol and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-vilanterol belongs to Respiratory; Primidone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by primidone and its metabolite phenobarbital.
What to do
Monitor respiratory symptoms and step up therapy if control worsens. No empiric dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-vilanterol
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Primidone?
MediHelp rates the interaction as minor. Fluticasone-vilanterol and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Primidone is partly converted to phenobarbital, a CYP3A4 inducer, so it may lower systemic levels of fluticasone furoate and vilanterol. The clinical effect is probably small but could reduce disease control.
How serious is the interaction between Fluticasone-vilanterol and Primidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptoms and step up therapy if control worsens. No empiric dose change is needed.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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