Drug interactions
Fluticasone-vilanterol + Quinine
Severity: Moderate
Fluticasone-vilanterol and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine prolongs the QT interval and may cause arrhythmias, and beta-2 agonists can add tachycardia and hypokalemia. The combination may increase the risk of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Fluticasone-vilanterol and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Quinine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation and adrenergic cardiac stimulation.
What to do
Check ECG and electrolytes in patients with cardiac disease or other QT risk factors, and monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Quinine?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine prolongs the QT interval and may cause arrhythmias, and beta-2 agonists can add tachycardia and hypokalemia. The combination may increase the risk of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Fluticasone-vilanterol and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with cardiac disease or other QT risk factors, and monitor for palpitations or syncope.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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