Drug interactions
Fluticasone-vilanterol + Rasagiline
Severity: Moderate
Fluticasone-vilanterol and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is a MAO-B inhibitor and may theoretically potentiate the cardiovascular effects of beta-2 agonists. At recommended doses the selectivity makes a clinically significant interaction less likely than with non-selective MAOIs.
What this interaction means in plain words
Fluticasone-vilanterol and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Rasagiline belongs to Central Nervous System.
Why it happens
MAO inhibition may increase catecholamine effects and potentiate adrenergic cardiovascular stimulation.
What to do
Monitor heart rate and blood pressure when starting the combination and use the lowest effective vilanterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Rasagiline?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rasagiline is a MAO-B inhibitor and may theoretically potentiate the cardiovascular effects of beta-2 agonists. At recommended doses the selectivity makes a clinically significant interaction less likely than with non-selective MAOIs.
How serious is the interaction between Fluticasone-vilanterol and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting the combination and use the lowest effective vilanterol dose.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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