Drug interactions
Fluticasone-vilanterol + Selegiline
Severity: Moderate
Fluticasone-vilanterol and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is a MAO-B inhibitor that may theoretically potentiate the cardiovascular effects of beta-2 agonists. At low oral doses the risk is limited, but it rises at higher doses when selectivity is lost.
What this interaction means in plain words
Fluticasone-vilanterol and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Selegiline belongs to Central Nervous System.
Why it happens
MAO inhibition may increase catecholamine effects and potentiate adrenergic cardiovascular stimulation.
What to do
Monitor heart rate and blood pressure, particularly with higher selegiline doses or transdermal use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Selegiline?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selegiline is a MAO-B inhibitor that may theoretically potentiate the cardiovascular effects of beta-2 agonists. At low oral doses the risk is limited, but it rises at higher doses when selectivity is lost.
How serious is the interaction between Fluticasone-vilanterol and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, particularly with higher selegiline doses or transdermal use.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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