Drug interactions
Fluticasone-vilanterol + Sorafenib
Severity: Moderate
Fluticasone-vilanterol and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib can prolong the QT interval, and vilanterol, a long-acting beta-2 agonist, can cause tachycardia, hypokalemia and QT changes. Used together they may add to the risk of arrhythmia, although the inhaled dose of vilanterol is low.
What this interaction means in plain words
Fluticasone-vilanterol and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Sorafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and adrenergic cardiovascular stimulation.
What to do
Check baseline ECG and electrolytes (potassium, magnesium) and correct any deficits. Monitor QTc and heart rhythm during treatment, and report palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Sorafenib
Frequently asked questions
Can I take Fluticasone-vilanterol with Sorafenib?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib can prolong the QT interval, and vilanterol, a long-acting beta-2 agonist, can cause tachycardia, hypokalemia and QT changes. Used together they may add to the risk of arrhythmia, although the inhaled dose of vilanterol is low.
How serious is the interaction between Fluticasone-vilanterol and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes (potassium, magnesium) and correct any deficits. Monitor QTc and heart rhythm during treatment, and report palpitations or syncope.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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