Drug interactions
Fluticasone-vilanterol + Sunitinib
Severity: Moderate
Fluticasone-vilanterol and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib can prolong the QT interval, and vilanterol may add to arrhythmic risk through adrenergic stimulation and a fall in potassium. The systemic exposure to inhaled vilanterol is low, so the clinical effect is usually modest.
What this interaction means in plain words
Fluticasone-vilanterol and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Sunitinib belongs to Oncology.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and heart rate.
What to do
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia. Monitor QTc periodically during co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluticasone-vilanterol and Sunitinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluticasone-vilanterol
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Sunitinib?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sunitinib can prolong the QT interval, and vilanterol may add to arrhythmic risk through adrenergic stimulation and a fall in potassium. The systemic exposure to inhaled vilanterol is low, so the clinical effect is usually modest.
How serious is the interaction between Fluticasone-vilanterol and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia. Monitor QTc periodically during co-therapy.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
