Drug interactions
Fluticasone-vilanterol + Timolol
Severity: Major
Fluticasone-vilanterol and Timolol: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic timolol blocks beta-2 receptors and can reduce or abolish the bronchodilation produced by vilanterol, with a risk of bronchospasm in patients with airway disease. Even ophthalmic timolol can be absorbed enough to cause bronchospasm in susceptible patients.
What this interaction means in plain words
Fluticasone-vilanterol and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Timolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism through non-selective beta-receptor blockade.
What to do
Avoid non-selective beta-blockers, including timolol eye drops, in patients with asthma or COPD; use a non-beta-blocker glaucoma agent or a cardioselective beta-blocker if one is needed. Monitor respiratory symptoms if co-therapy continues.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluticasone-vilanterol and Timolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Fluticasone-vilanterol
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Timolol?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic timolol blocks beta-2 receptors and can reduce or abolish the bronchodilation produced by vilanterol, with a risk of bronchospasm in patients with airway disease. Even ophthalmic timolol can be absorbed enough to cause bronchospasm in susceptible patients.
How serious is the interaction between Fluticasone-vilanterol and Timolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid non-selective beta-blockers, including timolol eye drops, in patients with asthma or COPD; use a non-beta-blocker glaucoma agent or a cardioselective beta-blocker if one is needed. Monitor respiratory symptoms if co-therapy continues.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
