Drug interactions
Fluvastatin + Fostemsavir
Severity: Moderate
Fluvastatin and Fostemsavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The active form of fostemsavir, temsavir, inhibits OATP1B1/3 and BCRP and can raise statin exposure. This increases the potential for muscle toxicity, though fluvastatin is less dependent on these pathways than rosuvastatin.
What this interaction means in plain words
Fluvastatin and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Fostemsavir belongs to Anti Virals.
Why it happens
Temsavir inhibits OATP1B1/3 and BCRP, reducing statin hepatic uptake and efflux.
What to do
Use the lowest effective fluvastatin dose and monitor for muscle symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fluvastatin with Fostemsavir?
MediHelp rates the interaction as moderate. Fluvastatin and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The active form of fostemsavir, temsavir, inhibits OATP1B1/3 and BCRP and can raise statin exposure. This increases the potential for muscle toxicity, though fluvastatin is less dependent on these pathways than rosuvastatin.
How serious is the interaction between Fluvastatin and Fostemsavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective fluvastatin dose and monitor for muscle symptoms.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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