Drug interactions
Fluvastatin + Leniolisib
Severity: Moderate
Fluvastatin and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP, OATP1B1 and OATP1B3, which are involved in the disposition of fluvastatin. Fluvastatin exposure may rise and increase the risk of myopathy.
What this interaction means in plain words
Fluvastatin and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Leniolisib belongs to Miscellaneous.
Why it happens
Leniolisib inhibits hepatic OATP uptake and BCRP efflux, increasing fluvastatin plasma levels.
What to do
Use the lowest effective fluvastatin dose and monitor for muscle symptoms, checking CK if they appear. Consider a different statin or a dose reduction if exposure effects are suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Leniolisib
Frequently asked questions
Can I take Fluvastatin with Leniolisib?
MediHelp rates the interaction as moderate. Fluvastatin and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits BCRP, OATP1B1 and OATP1B3, which are involved in the disposition of fluvastatin. Fluvastatin exposure may rise and increase the risk of myopathy.
How serious is the interaction between Fluvastatin and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective fluvastatin dose and monitor for muscle symptoms, checking CK if they appear. Consider a different statin or a dose reduction if exposure effects are suspected.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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