Drug interactions
Fluvastatin + Oteseconazole
Severity: Moderate
Fluvastatin and Oteseconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oteseconazole inhibits BCRP and can raise levels of BCRP substrates such as fluvastatin. Increased statin exposure raises the risk of muscle toxicity.
What this interaction means in plain words
Fluvastatin and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Oteseconazole belongs to Anti Fungals.
Why it happens
Oteseconazole inhibits BCRP, increasing fluvastatin absorption and reducing efflux.
What to do
Start with the lowest fluvastatin dose or reduce the dose, and monitor for myopathy symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Other interactions of Oteseconazole
- Atorvastatin + Oteseconazole Moderate
- Glyburide-metformin + Oteseconazole Moderate
- Glyburide + Oteseconazole Moderate
- Irinotecan + Oteseconazole Moderate
- Lapatinib + Oteseconazole Moderate
- Leflunomide + Oteseconazole Moderate
Frequently asked questions
Can I take Fluvastatin with Oteseconazole?
MediHelp rates the interaction as moderate. Fluvastatin and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oteseconazole inhibits BCRP and can raise levels of BCRP substrates such as fluvastatin. Increased statin exposure raises the risk of muscle toxicity.
How serious is the interaction between Fluvastatin and Oteseconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest fluvastatin dose or reduce the dose, and monitor for myopathy symptoms.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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