Drug interactions
Glyburide-metformin + Oteseconazole
Severity: Moderate
Glyburide-metformin and Oteseconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oteseconazole inhibits BCRP and may raise glyburide exposure. Higher glyburide levels could increase hypoglycemia risk.
What this interaction means in plain words
Glyburide-metformin and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Oteseconazole belongs to Anti Fungals.
Why it happens
BCRP inhibition by oteseconazole reduces glyburide efflux and clearance.
What to do
Monitor blood glucose during oteseconazole therapy. Use the lowest effective glyburide dose and reduce it if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Oteseconazole
- Atorvastatin + Oteseconazole Moderate
- Fluvastatin + Oteseconazole Moderate
- Glyburide + Oteseconazole Moderate
- Irinotecan + Oteseconazole Moderate
- Lapatinib + Oteseconazole Moderate
- Leflunomide + Oteseconazole Moderate
Frequently asked questions
Can I take Glyburide-metformin with Oteseconazole?
MediHelp rates the interaction as moderate. Glyburide-metformin and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oteseconazole inhibits BCRP and may raise glyburide exposure. Higher glyburide levels could increase hypoglycemia risk.
How serious is the interaction between Glyburide-metformin and Oteseconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during oteseconazole therapy. Use the lowest effective glyburide dose and reduce it if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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