Drug interactions
Fluvastatin + Paclitaxel
Severity: Minor
Fluvastatin and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel may inhibit OATP1B1 in vitro, but fluvastatin is mainly cleared by CYP2C9, and a clinically significant interaction has not been shown.
What this interaction means in plain words
Fluvastatin and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvastatin belongs to Cardiovascular; Paclitaxel belongs to Oncology.
Why it happens
Possible OATP1B1 inhibition; clinical relevance is unproven.
What to do
No dose change is needed. Monitor for muscle symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Paclitaxel
Frequently asked questions
Can I take Fluvastatin with Paclitaxel?
MediHelp rates the interaction as minor. Fluvastatin and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paclitaxel may inhibit OATP1B1 in vitro, but fluvastatin is mainly cleared by CYP2C9, and a clinically significant interaction has not been shown.
How serious is the interaction between Fluvastatin and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for muscle symptoms.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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