Drug interactions
Fluvastatin + Regorafenib
Severity: Minor
Fluvastatin and Regorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit BCRP, which handles fluvastatin efflux. Exposure to fluvastatin could increase, raising the potential for dose-related muscle adverse effects.
What this interaction means in plain words
Fluvastatin and Regorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvastatin belongs to Cardiovascular; Regorafenib belongs to Oncology.
Why it happens
Regorafenib inhibits BCRP (ABCG2), potentially reducing fluvastatin efflux.
What to do
Ask patients to report unexplained muscle pain or weakness, and check CK if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Regorafenib
Frequently asked questions
Can I take Fluvastatin with Regorafenib?
MediHelp rates the interaction as minor. Fluvastatin and Regorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Regorafenib may inhibit BCRP, which handles fluvastatin efflux. Exposure to fluvastatin could increase, raising the potential for dose-related muscle adverse effects.
How serious is the interaction between Fluvastatin and Regorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients to report unexplained muscle pain or weakness, and check CK if symptoms appear.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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