Drug interactions
Fluvastatin + Rifapentine
Severity: Moderate
Fluvastatin and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine is an inducer of hepatic enzymes and may lower fluvastatin exposure, potentially reducing LDL lowering. Effects are likely modest for fluvastatin.
What this interaction means in plain words
Fluvastatin and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP2C9 and other enzymes, increasing fluvastatin clearance.
What to do
Monitor lipids during and after rifapentine therapy and increase the fluvastatin dose if LDL control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Fluvastatin with Rifapentine?
MediHelp rates the interaction as moderate. Fluvastatin and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine is an inducer of hepatic enzymes and may lower fluvastatin exposure, potentially reducing LDL lowering. Effects are likely modest for fluvastatin.
How serious is the interaction between Fluvastatin and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipids during and after rifapentine therapy and increase the fluvastatin dose if LDL control is lost.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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