Drug interactions
Fluvastatin + Ritonavir
Severity: Moderate
Fluvastatin and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits hepatic uptake transporters and may raise fluvastatin concentrations, though fluvastatin is less affected than CYP3A4-dependent statins. Higher exposure could increase the risk of myopathy.
What this interaction means in plain words
Fluvastatin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Ritonavir belongs to Anti Virals.
Why it happens
Inhibition of OATP1B1 by ritonavir and possible variable effects on CYP2C9.
What to do
Fluvastatin is a reasonable statin choice with ritonavir at the lowest effective dose. Monitor for muscle pain or weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Fluvastatin with Ritonavir?
MediHelp rates the interaction as moderate. Fluvastatin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir inhibits hepatic uptake transporters and may raise fluvastatin concentrations, though fluvastatin is less affected than CYP3A4-dependent statins. Higher exposure could increase the risk of myopathy.
How serious is the interaction between Fluvastatin and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Fluvastatin is a reasonable statin choice with ritonavir at the lowest effective dose. Monitor for muscle pain or weakness.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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