Drug interactions
Fluvastatin + Sparsentan
Severity: Minor
Fluvastatin and Sparsentan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan can induce CYP2C9, the main enzyme clearing fluvastatin, which may lower fluvastatin levels. This could reduce cholesterol-lowering efficacy.
What this interaction means in plain words
Fluvastatin and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvastatin belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
Why it happens
Induction of CYP2C9 by sparsentan increasing fluvastatin metabolism.
What to do
Monitor lipid levels and increase the fluvastatin dose if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Fluvastatin with Sparsentan?
MediHelp rates the interaction as minor. Fluvastatin and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sparsentan can induce CYP2C9, the main enzyme clearing fluvastatin, which may lower fluvastatin levels. This could reduce cholesterol-lowering efficacy.
How serious is the interaction between Fluvastatin and Sparsentan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid levels and increase the fluvastatin dose if the response is inadequate.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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