Drug interactions
Fluvastatin + Warfarin
Severity: Moderate
Fluvastatin and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvastatin can raise the INR and the anticoagulant effect of warfarin in some patients. Bleeding has been reported after fluvastatin was added.
What this interaction means in plain words
Fluvastatin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Warfarin belongs to Cardiovascular.
Why it happens
Fluvastatin inhibits CYP2C9, the main enzyme clearing S-warfarin.
What to do
Check INR within the first week or so of starting or changing the fluvastatin dose and adjust warfarin accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluvastatin with Warfarin?
MediHelp rates the interaction as moderate. Fluvastatin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvastatin can raise the INR and the anticoagulant effect of warfarin in some patients. Bleeding has been reported after fluvastatin was added.
How serious is the interaction between Fluvastatin and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR within the first week or so of starting or changing the fluvastatin dose and adjust warfarin accordingly.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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