Drug interactions
Fluvoxamine + Fosamprenavir
Severity: Minor
Fluvoxamine and Fosamprenavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine is a weak to moderate CYP3A4 inhibitor and may modestly raise amprenavir exposure, the active metabolite of fosamprenavir. The effect is usually small and tolerable.
What this interaction means in plain words
Fluvoxamine and Fosamprenavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated metabolism of amprenavir by fluvoxamine.
What to do
No empirical dose change is usually needed; monitor for amprenavir adverse effects such as rash, gastrointestinal upset and lipid changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Fosamprenavir?
MediHelp rates the interaction as minor. Fluvoxamine and Fosamprenavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine is a weak to moderate CYP3A4 inhibitor and may modestly raise amprenavir exposure, the active metabolite of fosamprenavir. The effect is usually small and tolerable.
How serious is the interaction between Fluvoxamine and Fosamprenavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is usually needed; monitor for amprenavir adverse effects such as rash, gastrointestinal upset and lipid changes.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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