Drug interactions
Fluvoxamine + Gabapentin
Severity: Moderate
Fluvoxamine and Gabapentin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin causes sedation and dizziness, and fluvoxamine can add to drowsiness and psychomotor impairment. Respiratory depression is a concern mainly in patients with respiratory disease, in the elderly, or when other CNS depressants such as opioids are also used.
What this interaction means in plain words
Fluvoxamine and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Gabapentin belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects, which are pharmacodynamic.
What to do
Start gabapentin at a low dose and titrate slowly, and monitor for sedation, dizziness and breathing problems. Counsel the patient about driving and other hazardous tasks, and take extra care with other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluvoxamine and Gabapentin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Gabapentin
Frequently asked questions
Can I take Fluvoxamine with Gabapentin?
MediHelp rates the interaction as moderate. Fluvoxamine and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentin causes sedation and dizziness, and fluvoxamine can add to drowsiness and psychomotor impairment. Respiratory depression is a concern mainly in patients with respiratory disease, in the elderly, or when other CNS depressants such as opioids are also used.
How serious is the interaction between Fluvoxamine and Gabapentin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start gabapentin at a low dose and titrate slowly, and monitor for sedation, dizziness and breathing problems. Counsel the patient about driving and other hazardous tasks, and take extra care with other CNS depressants.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
