Drug interactions
Fluvoxamine + Indapamide
Severity: Moderate
Fluvoxamine and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine has a low QT-prolonging potential, and indapamide may add risk via electrolyte depletion and its own QT effect. Both can also contribute to hyponatremia.
What this interaction means in plain words
Fluvoxamine and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Indapamide belongs to Cardiovascular.
Why it happens
Additive QT effects and additive hyponatremia, with diuretic-induced hypokalemia and hypomagnesemia.
What to do
Monitor serum sodium, potassium and magnesium after starting the combination. Obtain an ECG if other QT-prolonging drugs or cardiac disease are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Indapamide?
MediHelp rates the interaction as moderate. Fluvoxamine and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine has a low QT-prolonging potential, and indapamide may add risk via electrolyte depletion and its own QT effect. Both can also contribute to hyponatremia.
How serious is the interaction between Fluvoxamine and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium, potassium and magnesium after starting the combination. Obtain an ECG if other QT-prolonging drugs or cardiac disease are present.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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