Drug interactions
Fluvoxamine + Indinavir
Severity: Minor
Fluvoxamine and Indinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine may modestly inhibit CYP3A4 and raise indinavir concentrations. This could increase indinavir-related effects such as nephrolithiasis and hyperbilirubinemia, but the effect is generally small.
What this interaction means in plain words
Fluvoxamine and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 metabolism of indinavir by fluvoxamine.
What to do
No empirical dose change is needed; maintain hydration and monitor for indinavir toxicity and renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Indinavir?
MediHelp rates the interaction as minor. Fluvoxamine and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine may modestly inhibit CYP3A4 and raise indinavir concentrations. This could increase indinavir-related effects such as nephrolithiasis and hyperbilirubinemia, but the effect is generally small.
How serious is the interaction between Fluvoxamine and Indinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; maintain hydration and monitor for indinavir toxicity and renal function.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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