Drug interactions
Fluvoxamine + Infigratinib
Severity: Moderate
Fluvoxamine and Infigratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine inhibits CYP3A4 and may raise infigratinib concentrations, increasing toxicities such as hyperphosphatemia and ocular effects.
What this interaction means in plain words
Fluvoxamine and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of infigratinib by fluvoxamine, which is a modest inhibitor.
What to do
Monitor for infigratinib toxicity including serum phosphate and eye symptoms. Consider an antidepressant with less CYP inhibition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Infigratinib?
MediHelp rates the interaction as moderate. Fluvoxamine and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine inhibits CYP3A4 and may raise infigratinib concentrations, increasing toxicities such as hyperphosphatemia and ocular effects.
How serious is the interaction between Fluvoxamine and Infigratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infigratinib toxicity including serum phosphate and eye symptoms. Consider an antidepressant with less CYP inhibition.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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