Drug interactions
Fluvoxamine + Irinotecan liposomal
Severity: Minor
Fluvoxamine and Irinotecan liposomal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irinotecan is mainly activated by carboxylesterases and inactivated by CYP3A4 and UGT1A1, with CYP2B6 playing at most a minor role. A clinically meaningful effect of fluvoxamine is not established.
What this interaction means in plain words
Fluvoxamine and Irinotecan liposomal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible minor CYP2B6 inhibition; mechanism not firmly established.
What to do
No adjustment is required; monitor routinely for neutropenia and diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Irinotecan liposomal?
MediHelp rates the interaction as minor. Fluvoxamine and Irinotecan liposomal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Irinotecan is mainly activated by carboxylesterases and inactivated by CYP3A4 and UGT1A1, with CYP2B6 playing at most a minor role. A clinically meaningful effect of fluvoxamine is not established.
How serious is the interaction between Fluvoxamine and Irinotecan liposomal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is required; monitor routinely for neutropenia and diarrhea.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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