Drug interactions
Fluvoxamine + Lamotrigine
Severity: Minor
Fluvoxamine and Lamotrigine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on the CNS and may add to drowsiness, dizziness and psychomotor slowing. A clinically important pharmacokinetic interaction is not well established, and serotonergic toxicity is not a recognized concern for lamotrigine.
What this interaction means in plain words
Fluvoxamine and Lamotrigine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Lamotrigine belongs to Central Nervous System.
Why it happens
Additive CNS effects, with no well-established pharmacokinetic mechanism.
What to do
No dose change is routinely needed, but monitor for excess sedation or dizziness when starting the combination. Counsel the patient about driving and other hazardous tasks.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Lamotrigine
Frequently asked questions
Can I take Fluvoxamine with Lamotrigine?
MediHelp rates the interaction as minor. Fluvoxamine and Lamotrigine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs act on the CNS and may add to drowsiness, dizziness and psychomotor slowing. A clinically important pharmacokinetic interaction is not well established, and serotonergic toxicity is not a recognized concern for lamotrigine.
How serious is the interaction between Fluvoxamine and Lamotrigine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed, but monitor for excess sedation or dizziness when starting the combination. Counsel the patient about driving and other hazardous tasks.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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